Week 5 of the 2025 NFL season kicked off Thursday night with a divisional showdown between the 49ers and Rams. San Francisco came out on top, earning a 26-23 overtime win after stopping Los Angeles on fourth-and-1 at the 11-yard line to seal the victory.
Sunday’s action began in London, where the Vikings defeated the Browns. Back in the U.S., the Texans rolled past the Ravens in dominant fashion, winning by 34 points. The Saints picked up their first win of the season against the Giants, while the Eagles suffered their first loss, falling to the Broncos.
In the late-afternoon slate, the Buccaneers edged the Seahawks in a close game, and the Titans rallied late to beat the Cardinals.
On Sunday night, the Patriots handed the Bills their first loss of the year, and the Jaguars closed out the week with a statement Monday night win over the Chiefs.
Week 6 Picks (Week 5 Pick Results: 6-8)
- Philadelphia Eagles over New York Giants
- Denver Broncos over New York Jets
- Indianapolis Colts over Arizona Cardinals
- Los Angeles Chargers over Miami Dolphins
- New England Patriots over New Orleans Saints
- Pittsburgh Steelers over Cleveland Browns
- Dallas Cowboys over Carolina Panthers
- Jacksonville Jaguars over Seattle Seahawks
- Los Angeles Rams over Baltimore Ravens
- Las Vegas Raiders over Tennessee Titans
- Green Bay Packers over Cincinnati Bengals
- Tampa Bay Buccaneers over San Francisco 49ers
- Detroit Lions over San Francisco 49ers
- Buffalo Bills over Atlanta Falcons
- Chicago Bears over Washington Commanders
